Knowledge gaps that hamper prevention and control ofMycobacterium aviumsubspeciesparatuberculosisinfection

Key Knowledge Gaps for Plasmodium vivax Control and Elimination

There is inadequate understanding of the biology, pathology, transmission, and control of Plasmodium vivax, the geographically most widespread cause of human malaria. During the last decades, study of this species was neglected, in part due to the erroneous belief that it is intrinsically benign. In addition, many technical challenges in culturing the parasite also hampered understanding its fu...

Representing Knowledge Gaps Effectively

In knowledge acquisition, one typically encounters two difficult situations: First, there are times when the system requests information that, due to a lack of information, the user is not in a position to provide at the level of precision requested. Second, there are situations where the system cannot capture information at the level of precision the user wishes to provide. We describe the tec...

Gaps in Menopause Knowledge

The average middle aged woman goes through a volatile period of endocrine fluctuations as she passes through menopause and the stages that precede and follow it. Ovarian hormones are steroid hormones. They readily cross the cell and nuclear membranes and influence transcription of numerous genes. Such influences are tissue specific and state specific. In short, changes in ovarian hormones mean ...

The CLI Knowledge Gaps

Critical Limb Ischemia as a Public Health Crisis Peripheral artery disease (PAD) is one of the most common cardiovascular diseases and is associated with high short-term morbidity and mortality. It is the primary cause of lower extremity amputation throughout the world and is a powerful marker of advanced systemic atherosclerosis. Chronic critical limb ischemia (CLI) represents the most advance...

Closing the knowledge gaps.